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This Statement was prepared to give you information about toluene and to emphasize the human health effects that may result from exposure to it. Very few studies of the nervous system have been performed at levels below 1000 ppm and most of the results were inconclusive. [Benignus VA; Neurobehav Toxicol Teratol 3 (4): 407-15 (1981)]**PEER REVIEWED** Lethal levels 1.0 mg%; 10.0 ug/ml [Winek, C. ]**PEER REVIEWED** IN EXPERIMENTS IN VITRO, DID NOT CHANGE NUMBER OF SISTER-CHROMATID EXCHANGES OR THE NUMBER OF CHROMOSOMAL ABERRATIONS IN HUMAN LYMPHOCYTES. Blood, urine and cerebrospinal fluid analysis appeared normal. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. V71 845 (1999)]**PEER REVIEWED** Renal tubular acidosis is one of a number of human complications reported in the offspring of mothers inhaling . Sax's Dangerous Properties of Industrial Materials. was detected in the workplace air of glass fiber manufacturing plants and high temperature sealing component and clutch lining plants at a mean concn of 65 ppm(4). Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. In the sixteen hours daily exposed rats two weeks of inhalation produced a significant reduction in the theta-wave frequency.

The Environmental Protection Agency (EPA) has identified 1,350 hazardous waste sites as the most serious in the nation. [GERNER-SCMIDT P, FRIEDRICH U; MUTATION RESEARCH 58: 313 (1978)]**PEER REVIEWED** A 28 yr old painter who was believed to be a habitual sniffer was admitted to Chiba Emergency Medical Center on several occasions. Deep tendon reflexes were all exaggerated, but there was no pathological reflex. Electroencephalography showed 40-50 u V, 9-10 c/s alpha waves with a few fast waves. Characteristics of this condition are described as well as its medical management. [(1) Hollund BE, Moen BE; Ann Occup Hyg 42: 277-81 (1998) (2) Eitzer BD; Environ Sci Technol 29: 896-902 (1995) (3) Brandorff NP et al; Occup Environ Med 52: 454-63 (1995) (4) Angerer J, Kraemer A; Int Arch Occup Environ Health 69: 91-96 (1997)]**PEER REVIEWED** Body Burden: in the blood and urine of workers in glass fiber and clutch lining plants were 911 ug/l and 2.9 mg/l, respectively(6). Monitor cardiac rhythm and treat arrhythmias if necessary ... Start an IV with D5W /SRP: "To keep open", minimal flow rate/. This change was also reached after either weeks of exposure in the eight hours daily exposed group.

The following information will answer all your questions about how to test for Toluene, how to clean your air of it, and health effects if you have been exposed to it. 1455]**PEER REVIEWED** WORKERS IN PHARMACEUTICAL PLANT IN FRANCE EXPOSED TO DEVELOPED LEUKOPENIA, & NEUTROPENIA. [MAKI-PAAKKANEN J ET AL; J TOXICOL ENVIRON HEALTH 6: 775 (1980)]**PEER REVIEWED** Patients (3) with history of recurrent abuse were hospitalized and severe metabolic acidosis, electrolyte abnormalities, hypoalkemia, and muscular weakness were present. [Goodwin TM; Obstet Gynecol 71: 715-18 (1988) as cited in U. Dept Health & Human Services/Agency for Toxic Substances & Disease Registry; Toxicological Profile for Toluene (Update) p.36 (1994) ATSDR/TP-93/14]**PEER REVIEWED** Exposure of students to 75 or 150 ppm for 7 hr caused a dose-related impairment of function on digit span, pattern recognition, the one hole test, and pattern memory. There were no differences in the results on simple reaction time, POMS mood scale, visual memory, hand-eye coordination, Sternberg test, finger tapping, reaction time, continuous performance test, and critical tracking test. Higher concentrations progressively reduced responding. The ED50 (the concentration reducing responding by 50%) averaged 1657 ppm in 10 mice.

Contact your local emergency services or The National Poison Control Center (1-800-222-1222) from anywhere in the United States. You should call if you have any questions about Toluene poisoning or Toluene poison prevention. You can call for any reason, 24 hours a day, 7 days a week. WITHIN 6 MO, THOSE AFFECTED SHOWED INCR IN CLOTTING TIME & DECR IN PROTHROMBIN LEVEL ... Distal renal tubular acidosis was believed to be present in 2/3 patients. There was an effect on the results of the symbol digit test but the effect was not dose related. [Echeverria D et al; Br J Ind Med 48: 750-61 (1991) as cited in U. Dept Health & Human Services/Agency for Toxic Substances & Disease Registry; Toxicological Profile for Toluene (Update) p.40 (1994) ATSDR/TP-93/14]**PEER REVIEWED** A group of 95-104 workers exposed to TWA of 41-46 ppm during shoemaking, printing, and audio equipment production were evaluated for symptoms and signs of exposure when compared to 130 control subjects. 182]**PEER REVIEWED** is not classifiable as to its carcinogenicity to humans (Group 3). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. It is estimated that there is a 1/1000 chance /ED001/ of the responding of a mouse being reduced by as much as 10% by a concentration of of 69 ppm.

The differential diagnostic examination showed in 51 of these 55 subjects an association with competing factors such as alcohol abuse (78%) and overweight (40%), to a slight extent disorders of fat and carbohydrate metabolism and of the gallbladder. The variance and regression analyses of the biochemical data have shown that alcohol significantly and considerably increases the activities of all three enzymes tested.

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is not classifiable as to its carcinogenicity to humans (Group 3). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. 1) Diffuse demyelination and gliosis of the cerebral and cerebella white matter. [Sakata E et al; Pract Otal Kyoto 79 (12): 1999-2013 (1986)]**PEER REVIEWED** Severe, acute in man and to the choice of reference parameters to monitor intoxication. 166]**PEER REVIEWED** Eye and upper airway irritation occurred after a 6.5 hr exposure to an air level of 100 ppm (377 mg/cu m) , and lachrymation was seen at 500 mg/cu m. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. The alterations reported here support the few earlier reports of morphological alterations in the CNS of adult laboratory animals.

It is proven to be one of the most effective air cleaners on the market today and will likely clean your air of both solids and gases such as Toluene and Formaldehyde with the highest efficiency compared to other air purifiers. Adverse effects included reduced appetite, nightmares, vertical nystagmus, and incoordination. Lower level acute exposures in man produce dizziness, exhilaration and confusion. Schedule controlled behaviors have been reported to produce inverted U-shaped concentration-effect curves on response rate measures. In each incident the acidosis was resolved within 3 days of birth. Tokyo, Japan: The International Technical Information Institute, 1988., p. 526]**PEER REVIEWED** Probable Routes of Human Exposure: NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,625,598 workers (288,299 of these are female) are potentially exposed to were documented: manufacturing of metals, 420; manufacturing of metal fabricated products 64,000; electrical machinery and apparatus, 1,500; manufacture of transport equipment 2,700; painters and carpenters 15,000; construction workers, 5,400; publishing and printing, 6,300; wholesale trades, 5,000; textile and leather manufacturing, 4,400; wood and furniture manufacturing, 5,900; manufacture of chemicals, 8,700; manufacture of paints and petroleum, 1,400; manufacture of non-metallic mineral products, 2,300; manufacture of optical instruments, 2,500 manufacture of plastic and boat building, 1,100; sewage and refuse disposal, 99; agriculture and forestry, 11,000; health services, 2,600. Use proparacaine hydrochloride to assist eye irrigation ... /Aromatics hydrocarbons and related compounds/ [Bronstein, A. FOUR TIMES THERAPEUTIC DOSE RATE PRODUCED NO OBSERVABLE CHANGES IN ... Each point on the frequency versus time plot were further analysed by Student's t-test.

IQ Air GC Chemisorber contains an impressive 12 pounds of the advanced Carbon-Potassium Permanganate filter media and has a very sophisticated gas filtration cartridge system plus highly efficient HEPA filtration for the removal of the tiniest of solid particulates as well. Alterations at levels as low as 150 ppm have been reported when appetitive contingencies are used. Pittsburgh, PA: Allied Fischer Scientific, 1985., p. [Lindemann R; Acta Pediatr Scand 80: 882-4 (1991) as cited in U. Dept Health & Human Services/Agency for Toxic Substances & Disease Registry; Toxicological Profile for Toluene (Update) p.49 (1994) ATSDR/TP-93/14]**PEER REVIEWED** Several case series have demonstrated that high exposure to through sniffing during pregnancy induces a syndrome that closely resembles the fetal alcohol syndrome, with pre- and postnatal growth deficiency, microcephaly and developmental delay, typical craniofacial features including micrognathia, small palpebral fissures, and ear anomalies. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. 526]**PEER REVIEWED** The clinical examination should include hemocytometric testing and a thrombocyte (platelet) count in view of the possibility that may contain a certain proportion of benzene. The total number of work related exposure events was 140,000(3). 181-2]**PEER REVIEWED** Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Compared to the non-exposed group the eight hours daily exposed showed an initial period of increased frequency of the regular theta-waves together with an increased incidence of theta-activity after 1-2 weeks of exposure.

On the other hand, in subjects with a higher alcohol intake the activities of liver enzymes in highly exposed workers.

[Boewer C et al; Int Arch Occup Environ Health 60 (3): 181-6 (1988)]**PEER REVIEWED** General health effects include lethality, growth, morbidity, liver and kidney damage and miscellaneous effects.

Performances of the two printer groups were similar with rotogravure printers having statistically significant lower scores on tests measuring visual cognitive abilities. Multimedia Environmental Goals for Environmental Assessment. Complaints of impaired memory, personality changes, and loss of confidence persisted 8 months after exposure.

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