She appears in the programme from the fifth series (2010) to midway through the seventh series (2012).
The Doctor first meets Amelia when she is seven years old (Caitlin Blackwood) and disturbed by a crack in her wall (that is actually one of several cracks in the universe).
They receive an anonymous invitation to the Utah desert where they reunite with the Doctor —now aged nearly two hundred years since they have last met —and fellow invitee River Song.
Amy witnesses the Doctor's death at the hand of an astronaut in an Apollo space suit, but they discover the Doctor also invited a younger version of himself, with whom they travel to 1969 Washington, D. to investigate strange occurrences involving the Silence, an alien race who cannot be remembered after they are encountered.
When the Doctor returns, Amy is nineteen years old and working as a kissogram.
She helps him save Earth from the galactic police force the Atraxi, and when he returns two years later she begins travelling with him as his companion.
He promises Amelia that he will return in five minutes, but is inadvertently late by twelve years.
In the intervening period, Amelia's family and friends believe the Doctor is just her imaginary friend; her insistence that he is real leads to her being treated by psychiatrists.
Amy is later persuaded by the Doctor to let her adult daughter make her own way in life.In "A Good Man Goes to War", her baby —named Melody Pond —is kidnapped by the eye-patched woman, Madame Kovarian, who will train her to one day kill the Doctor.River Song then arrives and tells Amy that she is an adult Melody.Amy awakes on her wedding day in a timeline where her parents are again part of reality and marries a restored Rory.Her memories are stirred by the TARDIS-shaped diary River Song (Alex Kingston) leaves for her.A flashback in "Let's Kill Hitler" introduces Amy and Rory's childhood friend Mels (Nina Toussaint-White).